David Kipling Selected Research

SB 203580

1/2016	The effect of RO3201195 and a pyrazolyl ketone P38 MAPK inhibitor library on the proliferation of Werner syndrome cells.
1/2013	The effect of small-molecule inhibition of MAPKAPK2 on cell ageing phenotypes of fibroblasts from human Werner syndrome.
12/2011	Investigating the role of c-Jun N-terminal kinases in the proliferation of Werner syndrome fibroblasts using diaminopyridine inhibitors.
6/2010	Use of p38 MAPK Inhibitors for the Treatment of Werner Syndrome.
6/2010	Evaluating the role of p38 MAP kinase in growth of Werner syndrome fibroblasts.
4/2007	The role of cellular senescence in Werner syndrome: toward therapeutic intervention in human premature aging.
5/2006	Prevention of accelerated cell aging in the Werner syndrome.
11/2005	Prevention of accelerated cell aging in Werner syndrome using a p38 mitogen-activated protein kinase inhibitor.

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David Kipling Research Topics

Disease

19	Werner Syndrome (Werner's Syndrome) 04/2016 - 04/2003
13	Neoplasms (Cancer) 06/2018 - 05/2003
3	Genomic Instability 02/2013 - 04/2007
2	Inflammation (Inflammations) 01/2020 - 10/2009
2	Wounds and Injuries (Trauma) 03/2018 - 02/2003
2	Carcinogenesis 01/2018 - 01/2004
2	Human Influenza (Influenza) 06/2015 - 01/2012
2	Liposarcoma 01/2014 - 03/2010
2	Progeria (Hutchinson Gilford Syndrome) 02/2013 - 04/2004
2	Melanoma (Melanoma, Malignant) 05/2004 - 05/2003
1	COVID-19 01/2022
1	Acute Disease 01/2022
1	Parasitic Diseases (Parasitic Disease) 01/2020
1	Hyperplasia 01/2020
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2018
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 06/2015
1	Monoclonal Gammopathy of Undetermined Significance 06/2015
1	Nijmegen Breakage Syndrome 02/2015
1	Allergic Rhinitis 09/2014
1	Seasonal Allergic Rhinitis (Hay Fever) 09/2014
1	Rothmund-Thomson Syndrome (Syndrome, Rothmund-Thomson) 10/2013
1	Lung Diseases (Lung Disease) 12/2011
1	Pneumococcal Pneumonia 12/2011
1	Communicable Diseases (Infectious Diseases) 12/2011
1	Sarcoma (Soft Tissue Sarcoma) 03/2010
1	Breast Neoplasms (Breast Cancer) 01/2010
1	Lung Neoplasms (Lung Cancer) 01/2010
1	Vascular Calcification 10/2009
1	Ataxia Telangiectasia (Louis Bar Syndrome) 06/2009
1	Infections 02/2009
1	Insulin Resistance 01/2008
1	Premature Aging 11/2005

Drug/Important Bio-Agent (IBA)

13	p38 Mitogen-Activated Protein KinasesIBA 04/2016 - 11/2005
8	SB 203580IBA 01/2016 - 11/2005
7	Telomerase (Telomerase Reverse Transcriptase)IBA 03/2006 - 02/2003
5	Proteins (Proteins, Gene)FDA Link 06/2018 - 05/2003
5	Phosphotransferases (Kinase)IBA 12/2011 - 04/2007
4	5- amino- 1- (4- fluorophenyl)- 4- (3- (2,3- dihydroxypropoxy)benzoyl)pyrazoleIBA 01/2016 - 07/2008
3	Immunoglobulin E (IgE)IBA 01/2020 - 09/2014
3	KetonesIBA 01/2016 - 07/2008
3	DNA (Deoxyribonucleic Acid)IBA 08/2013 - 04/2003
3	VX-745IBA 09/2010 - 11/2009
3	Cyclin-Dependent Kinase Inhibitor p16IBA 01/2004 - 05/2003
2	Immunoglobulin G (IgG)IBA 01/2022 - 06/2015
2	Pharmaceutical PreparationsIBA 06/2018 - 11/2005
2	MAP-kinase-activated kinase 2IBA 06/2015 - 01/2013
2	Immunoglobulins (Immunoglobulin)IBA 06/2015 - 06/2015
2	Immunoglobulin Heavy Chains (Immunoglobulin Heavy Chain)IBA 09/2014 - 08/2013
2	VaccinesIBA 12/2011 - 02/2009
2	doramapimodIBA 06/2010 - 11/2006
1	Yellow Fever Vaccine (Vaccine, Yellow Fever)FDA Link 01/2022
1	AntibodiesIBA 01/2020
1	IgE Receptors (Fc epsilon RI)IBA 01/2018
1	3-pyridinylboronic acidIBA 06/2015
1	2-chloroquinolineIBA 06/2015
1	AcidsIBA 06/2015
1	BromidesIBA 06/2015
1	ParaproteinsIBA 06/2015
1	Immunoglobulin A (IgA)IBA 06/2015
1	GalactosidasesIBA 02/2015
1	Actins (F Actin)IBA 02/2015
1	Messenger RNA (mRNA)IBA 01/2014
1	Cysteine Dioxygenase (Dioxygenase, Cysteine)IBA 01/2014
1	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA 08/2013
1	A-Form DNA (A-DNA)IBA 02/2013
1	Pneumococcal Vaccines (Pneumococcal Polysaccharide Vaccine)IBA 01/2012
1	Adenosine Triphosphate (ATP)IBA 09/2010
1	Biological ProductsIBA 06/2010
1	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2010
1	Ifosfamide FDA LinkGeneric 03/2010
1	Doxorubicin (Adriamycin)FDA LinkGeneric 03/2010
1	Therapeutic UsesIBA 02/2010
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2010
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2009
1	Interleukin-8 (Interleukin 8)IBA 10/2009
1	Phosphates (Orthophosphate)IBA 01/2008
1	CalciumIBA 01/2008
1	VX (EDIM)IBA 09/2007
1	CarbamatesIBA 11/2006
1	Urea (Carbamide)FDA LinkGeneric 11/2006
1	pyrazoleIBA 11/2006
1	Mitogen-Activated Protein Kinase 14IBA 11/2006
1	CytokinesIBA 11/2005
1	Small Interfering RNA (siRNA)IBA 01/2004
1	Growth InhibitorsIBA 05/2003
1	beta-Galactosidase (Lactaid)IBA 02/2003

Therapy/Procedure

5	Therapeutics 06/2018 - 02/2003
1	Drug Therapy (Chemotherapy) 06/2018
1	Radiotherapy 06/2018